15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl-OH)

Farin crystalline foda;Insoluble a cikin ruwa da man fetur ether, mai narkewa a cikin ethyl acetate da methanol;mp shine 115-116 ℃;Takamaiman juyawa [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
An yi amfani da shi don haɗin polypeptide, azaman monomer kariyar amino acid.
An dakatar da O-benzyl-l-threonine a cikin maganin dioxane kuma acylated tare da tert-butylcarbonyl azide don samun samfurin danyen, wanda ethyl acetate ya fitar a pH na 9-10 sannan kuma ya sake sakewa.
Wani sashi mai aiki na thymic oietin Ⅱ na sirrin thymus.Thymoietin II wani fili ne na polypeptide guda ɗaya wanda aka keɓe daga hormone thymus.Ya ƙunshi amino acid 49, kuma guntuwar sarkar peptide da ta ƙunshi amino acid guda 5 tana da duk ayyukan physiological iri ɗaya da thymoietin II.Saboda haka, wannan guntun pentapeptide ana kiransa thymus pentapeptide.Farin daskare-bushewar taro ko foda.
Ɗaya daga cikin ayyukan thymus pentapeptide shine haifar da bambancin kwayar halitta T.Yana iya zaɓin haifar da canjin ƙwayoyin Thy-1-prothorax zuwa sel Thy-1+ T.Ana yin sulhuntawa ta bambance-bambancen tantanin T ta hanyar haɓaka matakan cAMP na ciki.Wani muhimmin aiki na thymus pentapeptides shine ɗaure ga takamaiman masu karɓa na sel T na jini na balagagge, haɓaka matakin cAMP na ciki, don haka haifar da jerin halayen ƙwayoyin cuta, wanda kuma shine tushen aikin immunomodulatory.A cikin yanayin jiki na yau da kullun, thymus pentapeptide ya nuna sakamako na motsa jiki na rigakafi, wanda zai iya haɓaka ƙimar haɓakar E rosette da ƙimar juzu'i na lymphocytes na splenic, haɓaka matakan daban-daban na amsawar rigakafi ta farko ko ta sakandare, da haɓaka adadin nau'in IgM da IgG ko IgA irin antibody kafa Kwayoyin.Thymus pentapeptide kuma na iya haɓaka aikin phagocytosis na macrophages, haɓaka aikin enzyme da aikin phagocytosis na neutrophils polymorphonuclear, haɓaka abun ciki na antibody mai kewayawa, da haɓaka aikin rigakafi na ƙwayoyin jajayen jini.Thymus pentapeptide zai iya kunna CD4 da CD8 tabbataccen sel, ta yadda takamaiman ƙwayoyin Tc zasu iya kiyaye tsawon rai, amma kuma zasu iya kunna ƙwayoyin Th kuma su haifar da aikin ƙwayoyin Ts.Abubuwan rigakafin cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan thymus pentapeptide suna da alaƙa da haɓaka ayyukan tantanin halitta TC.Adadin da ya dace na thymus pentapeptide zai iya ƙara yawan samar da interferon a cikin rigakafin kamuwa da cuta.Ƙaddamarwa da haɓaka bambance-bambancen T cell da maturation;CD4/CD8 yana kula da zama na al'ada ta hanyar daidaita rabon T lymphocyte subsets;Inganta aikin phagocytosis na macrophages;Haɓaka aikin rigakafi na jan jini;Ƙara aikin ƙwayoyin kisa na halitta;Ƙara matakin samar da interleukin-2 da maganganun mai karɓa;Haɓaka samar da γ interferon a cikin sel mononuclear na gefe na jini;Haɓaka ayyukan SOD a cikin jini.
Ana iya amfani da shi a cikin marasa lafiya marasa lafiya tare da rashin aikin rigakafi bayan aikin rediyo da chemotherapy.Maganin ciwon hanta B;Manyan ayyukan tiyata da cututtuka masu tsanani;Autoimmune cututtuka irin su rheumatoid amosanin gabbai, lupus erythematosus;Nau'in ciwon sukari na II, ciwon menopause;Mutumin da ke da raunin aikin rigakafi.