67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Nidanib, sinadari ne.Sunan sinadarai 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland na methyl] - 2 - oxygen -, methyl ester, (z) - Clinically, wannan samfurin da ake amfani da su bi idiopathic huhu fibrosis (IPF).
Nidanib ya yi nazarin marasa lafiya 1,529 tare da fibrosis na huhu na idiopathic (IPF) a cikin gwaji na asibiti da yawa.Bayanan aminci da aka gabatar sun dogara ne akan kwatancen marasa lafiya na 1061 da aka ba nidanib 150 MG sau biyu a rana da placebo a cikin makonni 52-mako 3, bazuwar, makafi biyu, nazarin sarrafa wuribo (INPULSIS-1 da INPULSIS-2).Mafi yawan al'amuran da suka fi dacewa da amfani da nidanib sun hada da gudawa, tashin zuciya da amai, ciwon ciki, rashin cin abinci, asarar nauyi, da haɓakar enzymes hanta.Da fatan za a koma zuwa [Tsarin Kariya] don gudanar da mummunan halayen da suka dace.Rarraba gaɓoɓin gaɓoɓin (SOC) na MedDRA yana ba da taƙaitaccen ra'ayi mara kyau da rarrabuwar mita.
Nidanib wani yanki ne na P-gp (duba Pharmacokinetics).A cikin takamaiman nazarin hulɗar miyagun ƙwayoyi, haɗakar gudanarwa na ketoconazole, mai hana P-gp mai ƙarfi, ƙara haɓaka zuwa nidanib zuwa sau 1.61 ta yanki a ƙarƙashin lanƙwasa (AUC) da sau 1.83 ta hanyar maida hankali mafi girma (Cmax).
A cikin binciken mu'amala da miyagun ƙwayoyi tare da mai ƙarfi P-gp inducer rifampicin, kamuwa da nidanib ya ragu zuwa 50.3%, kamar yadda aka auna ta wurin da ke ƙarƙashin lanƙwasa (AUC), idan aka haɗa shi da rifampicin idan aka kwatanta da Nidanib kadai.Ta hanyar maida hankali mafi girma (Cmax), ya ragu zuwa 60.3%.
Lokacin gudanar da haɗe tare da wannan samfur, masu hana P-gp masu ƙarfi (misali, ketoconazole ko erythromycin) na iya ƙara haɓakawa ga nidanib.A cikin waɗannan lokuta, haƙurin haƙuri ga nidanib yakamata a sa ido sosai.Gudanar da munanan halayen na iya buƙatar katsewa, rage allurai, ko dakatar da jiyya tare da wannan samfur (duba [Amfani da sashi]).
P-gp m inducers (misali, rifampicin, carbamazepine, phenytoin da St. John's wort) na iya rage kamuwa da nidanib.Ya kamata a yi la'akari da madadin haɗuwa tare da babu ko ƙaramar shigar da P-gp.