130622-05-8 Tert-butoxycarbonyl-D-glutamic acid (methyl ester) - methyl ester

Fluoroquinolones suna da bakan ƙwayoyin cuta mai faɗi, aiki mai ƙarfi na ƙwayoyin cuta, ƙarancin halayen mara kyau, ƙarancin nama mai kyau, babban yanayin rayuwa na baka, tazarar gudanarwa mai tsayi da gudanarwa mai dacewa.An fi amfani da su wajen magance cututtuka masu yaduwa kamar kamuwa da cututtukan numfashi da kamuwa da cutar urinary.Tsarin magungunan ƙwayoyin cuta na fluoroquinolone yana da alaƙa da kasancewar fluorine a matsayi na shida na mahaifa quinolone.
Duk da haka, a cikin shekaru 10 na baya-bayan nan, saboda matsa lamba da aka samu ta hanyar aikace-aikacen irin wannan nau'in kwayoyi, nau'in nau'in kwayoyi yana karuwa, musamman a cikin 'yan shekarun nan, quinolone-resistant Streptococcus pneumoniae yana da juriya, wanda ke jure wa penicillin. maganin rigakafi macrolide da quinolone maganin rigakafi.A lokaci guda, an gano cewa wasu fluoroquinolones na iya haifar da tsawaita tazara ta QTc na electrocardiogram, hepatotoxicity da phototoxicity, wanda ya iyakance aikace-aikacen su.
Don shawo kan gazawar da ke sama na fluoroquinolones, yana da gaggawa don haɓaka sabbin mahaɗan tsarin tare da kyakkyawan aiki na ƙwayoyin cuta, bakan ƙwayoyin cuta da ƙanƙanta yadda zai yiwu mummunan sakamako akan ƙwayoyin cuta da yawa.Jerin sabbin magungunan da ba su da amfani da fluoroquinolone (NFQ) kwanan nan da ke dauke da 8-methoxyl sun bambanta da maganin rigakafi na fluoroquinolone a cikin cewa ba su da fluorine a matsayi na 6 na quinolone mahaifa tsakiya, amma har yanzu suna da ƙarfi a cikin vitro antibacterial aiki.nemonoxacin sabon NFQ ne mai hana topoisomerase na kwayan cuta.
Idan aka kwatanta da fluoroquinolones a halin yanzu a kasuwa, Nenofloxacin yana wakiltar sabon nau'in magungunan tsarin.nemonocacin (TG-873870), sabon maganin quinolone wanda Procter & Gamble (P&G) ya kirkira, ya nuna babban aikin kashe kwayoyin cuta a kan nau'ikan cututtukan cututtukan da suka dace da asibiti, gami da Staphylococcus aureus da Streptococcus pneumoniae masu jurewa da yawa.Sakamakon gwajin da aka yi a cikin berayen da suka kamu da cutar ya nuna cewa tasirin ƙwayoyin cuta na wannan samfur ya fi ƙarfin yawancin quinolones na yanzu.Bugu da ƙari, samfurin yana da kyawawan kaddarorin pharmacokinetic kuma an jure shi sosai.