22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide kuma ana kiransa Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, ipratropium bromide.Farin lu'ulu'u ne mai ɗanɗano mai ɗaci.Matsayin narkewa 232 ℃-233 ℃.Mai narkewa a cikin ruwa, dan kadan mai narkewa a cikin ethanol, wanda ba zai iya narkewa a cikin sauran kaushi na kwayoyin halitta.Sunan sunadarai: Brominated α- (hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Yana da maganin anticholinergic, wanda yana da tasiri mai karfi na shakatawa akan ƙwayar tsoka mai santsi da kuma tasirin antiasthmatic akan cututtuka na huhu na kullum.Tasirinsa a bayyane yake, tasiri mai sauri da tsawon lokaci.Ipratropium bromide kuma yana sarrafa ƙwayar ƙwayar ƙwayar ƙwayar cuta kuma yana inganta motsi na ciliary, don haka rage ƙwayar sputum don inganta samun iska.A halin yanzu, raguwar sputum kuma yana kawar da bronchospasm wanda ya haifar da haushi na bronchi.Domin rigakafi da kuma lura da cutar asma da kuma asma na kullum mashako, musamman ga marasa lafiya da ba za su iya jure wa yin amfani da β-agonist tsoka rawar jiki, tachycardia.Ana iya amfani da wannan samfurin a hade tare da beta-agonists don haɓaka ingancin juna, kamar a hade tare da finoterol don samar da aerosol (BERODU - AL) don ciwon fuka, mashako na kullum da kuma emphysema.Idan aka kwatanta da β-adrenergic receptor stimulants (misali, isopropyl epinephrine), wannan samfurin yana da ƙarancin sakamako masu illa na zuciya da jijiyoyin jini, kuma idan aka kwatanta da β2-receptor stimulants (misali, Suquanling), wannan samfurin yana da tasiri mai ƙarfi na tsari akan ƙarar phlegm.
Fesa inhalation.40 ~ 80μg sau ɗaya, sau 2 ~ 4 a rana.Lokacin amfani da, da farko cire murfin harsashi, sanya murfin harsashi giciye ido a kan bututun ƙarfe, juye kwalbar ƙasa, ƙunshi harsashin murfin a baki, nufa ga makogwaro, tsotsa gas a lokaci guda, danna bututun. a kan bawul, shakar ruwa, riƙe numfashi na ɗan lokaci.Maimaita abin da ke sama sau ɗaya idan ya cancanta.Aerosol: 0.025% bayani.Tablet: 10mg/ kwamfutar hannu.
Za a iya maganin guba mai tsanani na anticholinergic tare da masu hana cholinesterase.
Abubuwan da ba su da kyau na ipratropium bromide suna kama da atropine, wanda zai iya haifar da bugun jini, ciwon kai, dizziness, tashin hankali, tashin zuciya, amai, ciwon gastrointestinal, rawar jiki, hangen nesa, bushe baki, tari, dysuria, haɓaka bayyanar cututtuka na numfashi da rash.
Ipratropium bromide shine mai adawa da muscarinic, bronchodilator, da gishiri isopropyl na AtropineN.
Ipratropiumbromide da Formoterol sun haɗu da wani ɓangare don kare huhu daga kumburi na kullum da kuma kara girman huhu, rage neutrophils ta hanyar hana aiki ta hanyar MMP-9.Ipratropiumbromide (1nM) yana haɓaka haɓakar calcium bromide, rage rarrabuwar gaba da ƙara ɗaurin annexin-V.Bayan maganin Ipratropiumbromide, hemolysis ya karu kadan amma mahimmanci.Ipratropiumbromide yana haifar da mutuwar kwayar cutar jajayen jini ko eryptosis, da farko saboda haɓakar calcium.
Ipratropium bushe foda inhalation (DPI) ya kasance mai tasiri bronchodilator a hutawa dawakai a kashi na 2400 MG / doki, tare da kadan tasiri a kan saman iska caliber a lokacin dawowa.A cikin berayen da aka yi wa cadmium, Ipratropium ya rage yawan ƙwayar ƙwayar ƙwayar cuta ta parenchymal kuma an lura da cunkoson huhu masu cunkoso.Ipratropium wani bangare yana kare huhu daga kumburi ta hanyar rage shigar da neutrophil.A cikin guinea alade tracheal santsi tsoka, Ipratropium antagonist ne wanda ya hana prebound muscarinic inhibitory mai karɓa na huhu parasympathetic jijiya.An kuma nuna Ipratropium a matsayin mai karfin antagonist bayan-daure ga masu karɓar masu hana muscarinic.Ipratropium yana rage matsakaicin canje-canje a cikin matsa lamba na ƙirji kuma yana ƙara haɓaka mai ƙarfi (Cdyn) a cikin numfashin tidal (ƙarin Pplmax) da juriya na huhu (RL) a cikin dawakai.