171596-29-5 Tadalafil

Tadalafil, tare da tsarin kwayoyin C22H19N3O4 da nauyin kwayoyin halitta 389.4, wanda aka yi amfani da shi sosai don magance rashin barci a cikin maza tun 2003 a karkashin sunan kasuwanci Cialis.A cikin 2008, Kamfanin Eli Lilly ya sayar da haƙƙin haɓaka kasuwanci don maganin PAH zuwa United Therapeutics.A cikin Yuni 2009, FDA ta amince da Tadafil don kula da marasa lafiya tare da hauhawar jini na huhu (PAH) a Amurka a ƙarƙashin sunan kasuwanci Adcirca.An kirkiro Tadafil a cikin 2003 a matsayin magani don maganin ED, kuma tasirin ya kasance mai tasiri 30min bayan gudanarwa, amma mafi kyawun sakamako shine 2h bayan gudanarwa, kuma tasirin zai iya wuce 36h, kuma abincin ba ya shafar tasirin.Matsakaicin tadafil shine 10 ko 20mg, shawarar farko da aka ba da shawarar shine 10mg, dangane da halayen mai haƙuri da halayen mara kyau.Nazarin kafin kasuwa ya nuna cewa bayan makonni 12 na gudanarwa na baki na 10 ko 20mg na tadafil, yawan amsawar sun kasance 67% da 81%, bi da bi.Yawancin karatu sun nuna cewa tadafil yana da inganci mafi kyau wajen magance ED.
Rashin aiki mara kyau: Tadanafil da sildenafil suna cikin nau'in nau'in phosphodiesterase guda 5 (PDE5), amma tsarin su ya bambanta da na karshen, kuma abinci mai yawa ba ya tsoma baki tare da sha.A karkashin jima'i motsa jiki, nitric oxide synthase (NOS) a cikin penile jijiya endings da vascular endothelial Kwayoyin catalyzes da kira na nitric oxide (NO) daga substrate L-arginine.NO yana kunna guanylate cyclase, wanda ke jujjuya guanosine triphosphate zuwa cyclic guanosine phosphate (cGMP), don haka kunna cyclic guanosine phospho-dependent protein kinase, yana haifar da raguwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta. soso da tashin hankali.Nau'in phosphodiesterase 5 (PDE5) yana ƙasƙantar da cGMP zuwa samfuran marasa aiki, yana haifar da raunin penile.Ta hanyar hana lalata PDE5, tardanafil yana haifar da tarawar cGMP, wanda ke kwantar da tsoka mai laushi na corpus cavernosum na azzakari kuma yana haifar da haɓakar penile.Tun da esters nitrate BABU masu ba da gudummawa, haɗin su tare da tadanafil na iya ƙara girman matakin cGMP kuma ya haifar da rashin ƙarfi mai tsanani, sabili da haka, contraindications na asibiti na duka biyu suna contraindicated.
Tardanafil yana rinjayar wannan ta hanyar hana PDES.Lalacewar GMP, don haka idan aka yi amfani da shi tare da nitric acid da vinegar na iya haifar da matsananciyar faɗuwar hawan jini kuma yana ƙara haɗarin syncope.Wakilin induction na CY3PA4 na iya rage kasancewar tadana abiotic, kuma haɗe tare da rifampicin, cimetidine, erythromycin, clarithromycin, itraconwa, ketoconwa da masu hana masu hana HVI na iya ƙara yawan jinin wannan samfurin.Ya kamata a biya hankali ga daidaita kashi.Ya zuwa yanzu, babu wani rahoto kan sigogin magunguna na wannan samfurin da abinci da barasa ya shafa.
Yin amfani da D-tryptophan a matsayin albarkatun kasa, farkon methyl ester dauki, sakamakon D-tryptophan methyl ester hydrochloride a cikin isopropyl barasa da piperaldehyde Pictet-spengler dauki don samun cis-tetra hydrocarboline fili, sa'an nan dauki tare da chloroacetyl chloride da methylamine, jimlar. yawan amfanin ƙasa shine 56%, bayan an gwada, Glacial acetic acid an ƙara tsarkake shi azaman sauran ƙarfi recrystallization.Takamammun ma'aunin amsawa shine kamar haka:

Cialis shine Tadalafil, maganin baka wanda kamfanin Eli Lilly Pharmaceutical Company ya kirkira don maganin rashin karfin mazakuta.Mai hanawa na phosphodiesterase 5 ne na ƙarni na biyu.Rahotanni na bincike sun nuna cewa idan aka kwatanta da sildenafil, Cialis yana aiki da sauri sosai, kimanin minti 15 zuwa 20, kuma sakamakon ya kasance har zuwa 36 hours.T1/2 shine awanni 17.5.A cikin nazarin maza na 348 tare da rashin ƙarfi zuwa rashin ƙarfi mai tsanani wanda aka bazu don ɗaukar tadalafil 20mg ko placebo, duka 24 da 36 hours bayan shan miyagun ƙwayoyi sun inganta nasarar jima'i idan aka kwatanta da placebo, tare da yawancin maza sun sami nasarar yin jima'i sau biyu a 36 hours.Babu bambanci a cikin abin da ya faru da tsanani na mummunan halayen miyagun ƙwayoyi idan aka kwatanta da placebo.Fiye da 5% na maza a cikin ƙungiyar Tadalafil suna da ciwon kai da rashin narkewa.[Maganganun halayen] Ba a sami mummunan halayen da aka samu ba, kamar zubar da ruwa da rashin daidaituwar gani.Wani lokaci ciwon kai, dyspepsia.[Tsaurari] Marasa lafiya waɗanda ke shan nitrates, angina pectoris, cututtukan zuciya, hauhawar jini mara ƙarfi ko hauhawar jini, da marasa lafiya waɗanda suka sami bugun jini a cikin watanni 6 da suka gabata bai kamata a yarda ba.

Ana amfani da inhibitors na phosphodiesterase 5 don magance matsalar rashin ƙarfi a cikin maza.Ana amfani da masu hana phosphodiesterase 5 na ƙarni na biyu don magance tabarbarewar rashin ƙarfi a cikin maza.